by
Kelly K. HuntKelly K. Hunt

The possibility of treating cancer, a disease frequently defined by genetic defects, by introducing genes that target these very alterations has generated tremendous enthusiasm. This enthusiasm, howeverm has been tempered by an increasing number of obstacles to successful therapy, including vector systems that do not reach systemic metastasesm therapeutic genes with redundant mechanisms allowing for cellular resistance, and toxicities in clinical trails that result in premature closure. The three comprehensive sectiosn of this volume present currently available cancer gene therapy techniques, with specific attention to these trouble spots, Part I describes the various aspects of gene delivery including vehicles, or vectors, and their respective characteristics and production methods.